ATP-gated P 2 X 3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic β cell

@inproceedings{JacquesSilvaa2010ATPgatedP2,
  title={ATP-gated P 2 X 3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic β cell},
  author={M. Caroline Jacques-Silvaa and Mayrin Correa-Medinaa and Over Cabreraa and Rayner Rodriguez-Diaza and Natalia Makeevaa and Alberto Fachadoa and Juan Dieza and Dora M. Bermana and Norma S. Kenyona and Camillo Ricordia and Antonello Pileggia and R. Damaris Molanoa and Per-Olof Berggrena and Alejandro Caicedoa},
  year={2010}
}
  • M. Caroline Jacques-Silvaa, Mayrin Correa-Medinaa, +11 authors Alejandro Caicedoa
  • Published 2010
Extracellular ATP has been proposed as a paracrine signal in rodent islets, but it is unclear what role ATP plays in human islets. We now show the presence of an ATP signaling pathway that enhances the human β cell’s sensitivity and responsiveness to glucose fluctuations. By using in situ hybridization, RT-PCR, immunohistochemistry, and Western blotting as well as recordings of cytoplasmic-free Ca concentration, [Ca]i, and hormone release in vitro, we show that human β cells express ionotropic… CONTINUE READING

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