ATP drives direct photosynthetic production of 1-butanol in cyanobacteria.

@article{Lan2012ATPDD,
  title={ATP drives direct photosynthetic production of 1-butanol in cyanobacteria.},
  author={Ethan I Lan and James C. Liao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 16},
  pages={6018-23}
}
While conservation of ATP is often a desirable trait for microbial production of chemicals, we demonstrate that additional consumption of ATP may be beneficial to drive product formation in a nonnatural pathway. Although production of 1-butanol by the fermentative coenzyme A (CoA)-dependent pathway using the reversal of β-oxidation exists in nature and has been demonstrated in various organisms, the first step of the pathway, condensation of two molecules of acetyl-CoA to acetoacetyl-CoA, is… CONTINUE READING

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