ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.

@article{Mizuguchi2004ATPdrivenEO,
  title={ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex.},
  author={Gaku Mizuguchi and Xuetong Shen and J Brooke Landry and Wei Wu and Subhojit Sen and Carl H. Wu},
  journal={Science},
  year={2004},
  volume={303 5656},
  pages={343-8}
}
The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. Swr1 is… CONTINUE READING
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