ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis.


In quiescent thymocytes, mitochondrial de-energization was not correlated to apoptotic death. In fact, thymocytes treated with oligomycin, a highly specific inhibitor of ATP synthase, alone or with atractyloside to block ATP translocation from the cytoplasm, were alive, even if their mitochondria were depolarized, as revealed by flow cytometry after… (More)


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@article{Stefanelli1997ATPDI, title={ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis.}, author={Cesare Stefanelli and Francesca Bonavita and Ivana Stanic' and Giovanna Farruggia and Elisabetta Falcieri and Iole Robuffo and Clemente Pignatti and Claudio Muscari and Camila Rossoni and Carlo Guarnieri and Claudio Marcello Caldarera}, journal={The Biochemical journal}, year={1997}, volume={322 ( Pt 3)}, pages={909-17} }