ATP-dependent transport of statins by human and rat MRP2/Mrp2.

  title={ATP-dependent transport of statins by human and rat MRP2/Mrp2.},
  author={Lucy C J Ellis and Gabrielle M. Hawksworth and Richard J Weaver},
  journal={Toxicology and applied pharmacology},
  volume={269 2},
Multidrug resistance associated protein-2, MRP2 (human), Mrp2 (rat) are an efflux transporter, responsible for the transport of numerous endogenous and xenobiotic compounds including taurocholate, methotrexate and carboxydichlorofluorescein (CDF). The present study aims to characterise transport of statins by human and rat MRP2/Mrp2 using membrane and vesicle preparations. All statins tested (simvastatin, pravastatin, pitavastatin, fluvastatin, atorvastatin, lovastatin and rosuvastatin… CONTINUE READING


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