ATP-dependent transport of reduced glutathione in yeast secretory vesicles.

  title={ATP-dependent transport of reduced glutathione in yeast secretory vesicles.},
  author={James F Rebbeor and Gregory Clayton Connolly and Mark E Dumont and Nazzareno Ballatori},
  journal={The Biochemical journal},
  volume={334 ( Pt 3)},
Turnover of cellular reduced glutathione (GSH) is accomplished predominantly by export into the extracellular space; however, the plasma membrane transport mechanisms that mediate GSH efflux are not well characterized. The present study examined GSH transport using secretory vesicles isolated from the sec6-4 mutant strain of Saccharomyces cerevisiae. In contrast with studies in mammalian membrane vesicles, GSH transport in yeast secretory vesicles was mediated largely by an ATP-dependent, low… CONTINUE READING
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