ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.

@article{Keppler1998ATPdependentTO,
  title={ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.},
  author={Dietrich Keppler and Inka Leier and Gabriele Jedlitschky and J. Frank Koenig},
  journal={Chemico-biological interactions},
  year={1998},
  volume={111-112},
  pages={153-61}
}
The membrane proteins mediating the ATP-dependent transport of glutathione S-conjugates and related amphiphilic anions have been identified as the multidrug resistance proteins MRP1 and MRP2. These 190-kDa membrane glycoproteins were cloned in recent years and shown to be unidirectional, ATP-driven, export pumps with an amino acid identity of 49% in humans. MRP1 is detected in the plasma membrane of many cell types, including erythrocytes; whereas MRP2, also termed canalicular MRP (cMRP) or… CONTINUE READING

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