ATP-dependent steps in apoptotic signal transduction.

  title={ATP-dependent steps in apoptotic signal transduction.},
  author={Yuko Eguchi and Anu Srinivasan and Kevin J. Tomaselli and Saori Shimizu and Yoshihide Tsujimoto},
  journal={Cancer research},
  volume={59 9},
Apoptotic changes of the nucleus induced by Fas (Apo1/CD95) stimulation are completely blocked by reducing intracellular ATP level. In this study, we examined the ATP-dependent step(s) of Fas-mediated apoptotic signal transduction using two cell lines. In SKW6.4 (type I) cells characterized by rapid formation of the death-inducing signaling complex on Fas treatment, the activation of caspases 8, 9, and 3, cleavage of DFF45 (ICAD), and release of cytochrome c from the mitochondria to the… CONTINUE READING


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