ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia–ischemia in rats

@article{Ortega2012ATPdependentPC,
  title={ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia–ischemia in rats},
  author={Francisco J. Ortega and Javier Gimeno-Bay{\'o}n and Juan F. Espinosa-Parrilla and Josep Llu{\'i}s Carrasco and Montserrat Batlle and Marco Pugliese and Nicole Mahy and M. J. Rodr{\'i}guez},
  journal={Experimental Neurology},
  year={2012},
  volume={235},
  pages={282-296}
}
Stroke causes CNS injury associated with strong fast microglial activation as part of the inflammatory response. In rat models of stroke, sulphonylurea receptor blockade with glibenclamide reduced cerebral edema and infarct volume. We postulated that glibenclamide administered during the early stages of stroke might foster neuroprotective microglial activity through ATP-sensitive potassium (K(ATP)) channel blockade. We found in vitro that BV2 cell line showed upregulated expression of K(ATP… 
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