ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.

Abstract

Activation of translation initiation is a common trait of cancer cells. Formation of the heterotrimeric eukaryotic initiation factor F (eIF4F) complex is the rate-limiting step in 5' m7GpppN cap-dependent translation. This trimeric complex includes the eIF4E cap binding protein, the eIF4G scaffolding protein, and the DEAD box RNA helicase eIF4A. eIF4A is an… (More)
DOI: 10.1016/j.bmcl.2017.07.045

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