ATP binding properties of the nucleotide-binding folds of SUR1.

  title={ATP binding properties of the nucleotide-binding folds of SUR1.},
  author={Michinori Matsuo and Noriyuki Kioka and Teruo Amachi and Kazumitsu Ueda},
  journal={The Journal of biological chemistry},
  volume={274 52},
Pancreatic beta cell ATP-sensitive potassium (K(ATP)) channels regulate glucose-induced insulin secretion. The activity of the K(ATP) channel, composed of SUR1 and Kir6.2 subunits, is regulated by intracellular ATP and ADP, but the molecular mechanism is not clear. To distinguish the ATP binding properties of the two nucleotide-binding folds (NBFs) of SUR1, we prepared antibodies against NBF1 and NBF2, and the tryptic fragment of SUR1 was immunoprecipitated after photoaffinity labeling with 8… CONTINUE READING


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