ATP-binding cassette transporters in liver.

  title={ATP-binding cassette transporters in liver.},
  author={Katrin Wlcek and Bruno Stieger},
  volume={40 2},
The human ATP-binding cassette (ABC) superfamily consists of 48 members with 14 of them identified in normal human liver at the protein level. Most of the ABC members act as ATP dependent efflux transport systems. In the liver, ABC transporters are involved in diverse physiological processes including export of cholesterol, bile salts, and metabolic endproducts. Consequently, impaired ABC transporter function is involved in inherited diseases like sitosterolemia, hyperbilirubinemia, or… CONTINUE READING
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