ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation.

@article{YvanCharvet2010ATPbindingCT,
  title={ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation.},
  author={Laurent Yvan-Charvet and Tamara A. Pagler and Emmanuel L. Gautier and Serine Avagyan and Read L Siry and Seongah Han and Carrie L. Welch and Nan Wang and Gwendalyn J Randolph and Hans W Snoeck and Alan Richard Tall},
  journal={Science},
  year={2010},
  volume={328 5986},
  pages={1689-93}
}
Elevated leukocyte cell numbers (leukocytosis), and monocytes in particular, promote atherosclerosis; however, how they become increased is poorly understood. Mice deficient in the adenosine triphosphate-binding cassette (ABC) transporters ABCA1 and ABCG1, which promote cholesterol efflux from macrophages and suppress atherosclerosis in hypercholesterolemic… CONTINUE READING