ATP-binding cassette transporter G2 activity in the bovine spermatozoa is modulated along the epididymal duct and at ejaculation.

@article{Caballero2012ATPbindingCT,
  title={ATP-binding cassette transporter G2 activity in the bovine spermatozoa is modulated along the epididymal duct and at ejaculation.},
  author={Julieta Caballero and Gilles Frenette and Olivier D'amours and Maurice Dufour and Richard J Oko and Robert Sullivan},
  journal={Biology of reproduction},
  year={2012},
  volume={86 6},
  pages={181}
}
During their epididymal maturation, stabilizing factors such as cholesterol sulfate are associated with the sperm plasma membrane. Cholesterol is sulfated in epididymal spermatozoa by the enzyme estrogen sulfotransferase. Because of its role in the efflux of sulfate conjugates formed intracellularly by sulfotransferases, the ATP-binding cassette membrane transporter G2 (ABCG2) might have a role in the translocation of this compound across the plasma membrane. In the present study we showed that… CONTINUE READING
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