ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter.

  title={ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter.},
  author={Elizabeth J Tarling and Peter A. Edwards},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 49},
Four members of the mammalian ATP binding cassette (ABC) transporter G subfamily are thought to be involved in transmembrane (TM) transport of sterols. The residues responsible for this transport are unknown. The mechanism of action of ABCG1 is controversial and it has been proposed to act at the plasma membrane to facilitate the efflux of cellular sterols to exogenous high-density lipoprotein (HDL). Here we show that ABCG1 function is dependent on localization to intracellular endosomes… CONTINUE READING
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