ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells.

@article{Marty2005ATPBC,
  title={ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells.},
  author={Vincent Marty and Chantal M{\'e}dina and Chantal Combe and Patricia Parnet and Thierry Am{\'e}d{\'e}e},
  journal={Glia},
  year={2005},
  volume={49 4},
  pages={511-9}
}
Schwann cells are best known as myelinating glial cells of the peripheral nervous system, but they also participate actively in the sphere of immunity by producing pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta). In a previous study, we demonstrated that posttranslational processing of IL-1beta by immune-challenged Schwann cells required the P2X7 receptor. Remarkably, the release of IL-1beta was not associated with cell death, indicating the involvement of an active mechanism… CONTINUE READING

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