ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.

@article{Wang2003ATPbindingCT,
  title={ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux.},
  author={Nan Wang and Debin Lan and Marie C. Gerbod-Giannone and Patrick Linsel-Nitschke and Andreas Werner Jehle and Wengen Chen and Laurent Olivier Martinez and Alan Richard Tall},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 44},
  pages={42906-12}
}
ATP-binding cassette transporter 1 (ABCA1), the defective transporter in Tangier disease, binds and promotes cellular cholesterol and phospholipid efflux to apolipoprotein I (apoA-I). Based on a high degree of sequence homology between ABCA1 and ABCA7, a transporter of unknown function, we investigated the possibility that ABCA7 might be involved in apolipoprotein binding and lipid efflux. Similarly to cells expressing ABCA1, HEK293 cells overexpressing ABCA7 showed specific binding and cross… CONTINUE READING