ATP as a co-transmitter in rat tail artery.

@article{Sneddon1984ATPAA,
  title={ATP as a co-transmitter in rat tail artery.},
  author={Peter H Sneddon and Geoffrey Burnstock},
  journal={European journal of pharmacology},
  year={1984},
  volume={106 1},
  pages={149-52}
}
In rat tail artery the electrical response to nerve stimulation was biphasic, consisting of a fast, transient depolarisation which was resistant to alpha-adrenoceptor antagonists and a slow, prolonged depolarisation which was abolished by them. In the presence of alpha, beta-methylene-adenosine 5'-triphosphate (alpha, beta-methylene-ATP), which abolishes responses mediated via P2-purinoceptors, the fast depolarisation was abolished, whilst the slow depolarisation persisted. We propose that both… CONTINUE READING

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