ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4.

@article{Inoue2004ATPAA,
  title={ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4.},
  author={Kazuhide Inoue and Makoto Tsuda and Schuichi Koizumi},
  journal={Journal of pharmacological sciences},
  year={2004},
  volume={94 2},
  pages={112-4}
}
We have been studying the role of ATP receptors in pain and already reported that activation of P2X(2/3) heteromeric channel/receptor in primary sensory neurons causes acutely tactile allodynia, one hallmark of neuropathic pain. We report here that tactile allodynia under the chronic pain state requires an activation of the P2X(4) ionotropic ATP receptor and p38 mitogen-activated protein kinase (MAPK) in spinal cord microglia. Two weeks after L5 spinal nerve injury, rats displayed a marked… CONTINUE READING
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