ATP acts as a survival signal and prevents the mineralization of aortic valve.

@article{Ct2012ATPAA,
  title={ATP acts as a survival signal and prevents the mineralization of aortic valve.},
  author={Nancy C{\^o}t{\'e} and Diala El Husseini and Andr{\'e}e P{\'e}pin and Sandra Guauque-Olarte and Val{\'e}rie Ducharme and Pascale Bouchard-Cannon and Audrey Audet and Dominique Fournier and Nathalie Gaudreault and Habib Derbali and Marc D McKee and Chantale Simard and Jean-pierre Despr{\'e}s and Philippe Pibarot and Yohan Boss{\'e} and Patrick Mathieu},
  journal={Journal of molecular and cellular cardiology},
  year={2012},
  volume={52 5},
  pages={1191-202}
}
Calcific aortic valve disease (CAVD) is a disorder related to progressive mineralization of valvular tissue that is a leading cause of heart disease. Thus far, there is no medical treatment to prevent the mineralization of aortic valves. It is generally thought that pathologic mineralization is linked to apoptosis of vascular cells. However, the role of apoptosis during mineralization as well as the survival signals for valvular interstitial cells (VICs), the main cellular component of aortic… CONTINUE READING