ATP Synthase: The machine that makes ATP

@article{Pedersen1994ATPST,
  title={ATP Synthase: The machine that makes ATP},
  author={Peter L. Pedersen},
  journal={Current Biology},
  year={1994},
  volume={4},
  pages={1138-1141}
}
  • P. Pedersen
  • Published 1 December 1994
  • Chemistry
  • Current Biology
View on Elsevier
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29 Citations
Background Citations
11

29 Citations

Beyond being an energy supplier, ATP synthase is a sculptor of mitochondrial cristae.
Facts and Concepts in Cell Compartmentation
TLDR
Endomembranes completely enclose diverse compartments in eukaryotic cells that, due to their particular respective complements of enzymes, carry out variable metabolic functions.
ATPase-ATP Synthase and Mitochondrial Pathology
TLDR
The F0-Fl structure has been partly resolved and the mechanisms explaining how proton transfer across F0 could induce conformational changes inside Fl that would induce ATP synthesis are elucidated.
Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase.
Clostridium pasteurianum F1Fo ATP Synthase: Operon, Composition, and Some Properties
TLDR
The F1Fo complex from C. pasteurianum was activated by thiocyanate, cyanate, or sulfhydryl compounds; inhibited by sulfite, bisulfite, or bicarbonate; and had tolerance to inhibition by dicyclohexylcarbodiimide.
Physiological roles of the mitochondrial permeability transition pore
TLDR
Recent advances in understanding the molecular components of mPTP and its regulatory mechanisms have determined that decreased uncoupling occurs in states of enhanced mitochondrial efficiency; relative closure ofmPTP therefore contributes to cellular functions as diverse as cardiac development and synaptic efficacy.
Expression, purification, crystallization and preliminary X-ray crystallographic studies of a mitochondrial membrane-associated protein Cbs2 from Saccharomyces cerevisiae
TLDR
A preliminary X-ray crystallographic study was carried out to investigate the structural characteristics of how Saccharomyces cerevisiae Cbs2 tethers cytochrome b mRNA to the mitochondrial inner membrane, and indicated that the biological assembly of CBS2 may be a dimer.
Oxidative phosphorylation supercomplexes and respirasome reconstitution of the colorless alga Polytomella sp.
The Mitochondrial Permeability Transition Pore: Molecular Structure and Function in Health and Disease
TLDR
This chapter will discuss recent advances in understanding the molecular components of mPTP, its regulatory mechanisms during cell death, and its function in diseases of the brain.
ISOLATION, SUBFRACTIONATION AND ENZYMATIC ANALYSIS OF COW AND GOAT HEART MITOCHONDRIA
TLDR
The mitochondria are a double membrane bound organelle found in eukaryotic cell that contains large number of enzymes involved in diverse activities such as elongation of fatty acids, oxidation of epinephrine and degradation of tryptophan.
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References

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TLDR
The crystal structure of bovine mitochondrial F1-ATPase determined at 2.8 Ă… resolution supports a catalytic mechanism in intact ATP synthase in which the three catalytic subunits are in different states of the catalytic cycle at any instant.
Molecular architecture of chloroplast coupling factor 1
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Crystals of the F1-ATPase sector of the ATP synthase complex from bovine heart mitochondria have been grown from solutions containing polyethylene glycol 6000. The crystals diffract to 2.9 A…
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A unique class of suppressor mutations identify a transmembrane helix of subunita that is proposed to interact with the bihelical unit of subunitc during proton transport and the role of multiple units of sub unitc in coupling proton translocation to ATP synthesis is considered.
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TLDR
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