ATP-Sensitive K Channel – Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR 1 / Mouse-Cells

@inproceedings{Gromada2004ATPSensitiveKC,
  title={ATP-Sensitive K Channel – Dependent Regulation of Glucagon Release and Electrical Activity by Glucose in Wild-Type and SUR 1 / Mouse-Cells},
  author={Jesper Gromada and Xiaosong Ma and Marianne H\oy and Krister Bokvist and Albert Salehi and P. -O. Berggren and Patrik Rorsman},
  year={2004}
}
Patch-clamp recordings and glucagon release measurements were combined to determine the role of plasma membrane ATP-sensitive K channels (KATP channels) in the control of glucagon secretion from mouse pancreatic -cells. In wild-type mouse islets, glucose produced a concentration-dependent (half-maximal inhibitory concentration [IC50] 2.5 mmol/l) reduction of glucagon release. Maximum inhibition ( 50%) was attained at glucose concentrations >5 mmol/l. The sulfonylureas tolbutamide (100 mol/l… CONTINUE READING