ATP-Sensitive K+ Channel Mediates the Zinc Switch-Off Signal for Glucagon Response During Glucose Deprivation

@inproceedings{Slucca2010ATPSensitiveKC,
  title={ATP-Sensitive K+ Channel Mediates the Zinc Switch-Off Signal for Glucagon Response During Glucose Deprivation},
  author={Michela Slucca and Jamie S. Harmon and Elizabeth A. Oseid and Joseph Bryan and R. Paul Robertson},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE The intraislet insulin hypothesis proposes that glucagon secretion during hypoglycemia is triggered by a decrease in intraislet insulin secretion. A more recent hypothesis based on in vivo data from hypoglycemic rats is that it is the decrease in zinc cosecreted with insulin from beta-cells, rather than the decrease in insulin itself, that signals glucagon secretion from alpha-cells during hypoglycemia. These studies were designed to determine whether closure of the alpha-cell ATP… CONTINUE READING

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Immunoassay of insulin: two antibody system: plasma insulin levels of normal, subdiabetic, and diabetic rats

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