• Biology, Medicine
• Published in Front. Physiol. 2013
• DOI:10.3389/fphys.2013.00292

ATP Releasing Connexin 30 Hemichannels Mediate Flow-Induced Calcium Signaling in the Collecting Duct

@inproceedings{Svenningsen2013ATPRC,
  title={ATP Releasing Connexin 30 Hemichannels Mediate Flow-Induced Calcium Signaling in the Collecting Duct},
  author={Per Svenningsen and James L. Burford and J{\'a}nos Peti-Peterdi},
  booktitle={Front. Physiol.},
  year={2013}
}

• Per Svenningsen, James L. Burford, János Peti-Peterdi

ATP in the renal tubular fluid is an important regulator of salt and water reabsorption via purinergic calcium signaling that involves the P2Y2 receptor, ENaC, and AQP2. Recently, we have shown that connexin (Cx) 30 hemichannels are localized to the non-junctional apical membrane of cells in the distal nephron-collecting duct (CD) and release ATP into the tubular fluid upon mechanical stimuli, leading to reduced salt and water reabsorption. Cx30(-/-) mice show salt-dependent elevations in BP… CONTINUE READING

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