ATP Release from Vascular Endothelia Occurs Across Cx43 Hemichannels and Is Attenuated during Hypoxia

@article{Faigle2008ATPRF,
  title={ATP Release from Vascular Endothelia Occurs Across Cx43 Hemichannels and Is Attenuated during Hypoxia},
  author={Marion Faigle and Jessica Seessle and Stephanie Zug and Karim C. El Kasmi and Holger K. Eltzschig},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={1315 - 1323}
}
BACKGROUND Extracellular ATP is an important signaling molecule for vascular adaptation to limited oxygen availability (hypoxia). Here, we pursued the contribution of vascular endothelia to extracellular ATP release under hypoxic conditions. METHODOLOGY, PRINCIPAL FINDINGS We gained first insight from studying ATP release from endothelia (HMEC-1) pre-exposed to hypoxia. Surprisingly, we found that ATP release was significantly attenuated following hypoxia exposure (2% oxygen, 22+/-3% after 48… CONTINUE READING
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