ATP-MgCl2 treatment after experimental acute myocardial ischemia and reperfusion.

Abstract

BACKGROUND The effect of ATP-MgCl2 on myocardial metabolism and hemodynamics was investigated in this study. METHODS Twelve dogs were entered in this research. Six dogs received ATP-MgCl2 and the remaining dogs were considered as controls. The amount of ATP and MgCl2 concentration of this solution is 100 mumol/ml each. The volume administered to the animals during the aortic occlusion is 0.25 ml/kg/hour; in the solution are 100 mumol/ml dose each. The volume administered to the animals during reperfusion is 0.25 ml/kg/hour. The left anterior descending artery was occluded for a period of one hour and the drug was administered during reperfusion. RESULTS Three hours after reperfusion, cardiac output was 1524 +/- 26 ml/min in the control group and 1638 +/- 47 ml/min in the ATP-MgCl2 group (p < 0.05), pulmonary capillary wedge pressure was 14 +/- 3 in the control group and 8 +/- 2 in the ATP-MgCl2 group. At the same time interval tissue ATP and lactate level was 7 +/- 3, 1.3 +/- 0.4 in the control group and 14 +/- 2, 0.0 +/- 0.2 in the ATP-MgCl2 group respectively (p < 0.05). CONCLUSIONS In this study we demonstrated that ATP-MgCl2 usage after one hour of arterial occlusion protects the heart from the adverse effects of ischemia/reperfusion.

Cite this paper

@article{Katirciolu2000ATPMgCl2TA, title={ATP-MgCl2 treatment after experimental acute myocardial ischemia and reperfusion.}, author={Salih Fehmi Katircioğlu and Ahmet Tulga Ulus and Z{\"{u}lfikar Kadir Saritaş}, journal={Panminerva medica}, year={2000}, volume={42 1}, pages={11-5} }