ATP Binding Cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia.

@article{Winter2013ATPBC,
  title={ATP Binding Cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia.},
  author={Stuart S. Winter and Jerec W Ricci and Li Luo and Debbie Lovato and Hadya M. Khawaja and Tasha R Serna-Gallegos and Natalie Debassige and Richard S. Larson},
  journal={Health},
  year={2013},
  volume={5 5A}
}
PURPOSE In acute lymphoblastic leukemia (ALL), multidrug resistance is often mediated by ATPase Binding Cassette (ABC) proteins, which principally involve ABCB1 (multidrug resistance 1, MDR1) and ABCC1 (multidrug resistance protein 1, MRP1). However, direct comparisons between the differential effects of ABCB1 and ABCC1 have been difficult, since identical cell lines with differential expression of these transporters have not been developed. EXPERIMENTAL DESIGN In this study, we developed and… CONTINUE READING