ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP

Abstract

In this study we have investigated the role of extracellular ATP on thrombin induced-platelet aggregation (TIPA) in washed human platelets. ATP inhibited TIPA in a dose-dependent manner and this inhibition was abolished by apyrase but not by adenosine deaminase (ADA) and it was reversed by extracellular magnesium. Antagonists of P2Y1 and P2Y12 receptors had… (More)
DOI: 10.1371/journal.pone.0067117

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@inproceedings{Burzaco2013ATPAT, title={ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP}, author={Jaione Burzaco and Manuel Chaves Conde and Luis Antonio Parada and Jos{\'e} Luis Zugaza and Jean-Paul Dehaye and Aida Marino}, booktitle={PloS one}, year={2013} }