ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer

@article{Bernstein2003ATMV7,
  title={ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer},
  author={Jonine L. Bernstein and Leslie Bernstein and W. Douglas Thompson and Charles F. Lynch and Kathleen E. Malone and Susan L. Teitelbaum and J{\o}rgen H Olsen and Hoda Anton-Culver and John D Boice and Barry Rosenstein and A-L B{\o}rresen-Dale and Richard A. Gatti and Patrick Concannon and Robert W. Haile},
  journal={British Journal of Cancer},
  year={2003},
  volume={89},
  pages={1513 - 1516}
}
Recent reports suggest that two ATM gene mutations, 7271T>G and IVS10-6T>G, are associated with a high risk of breast cancer among multiple-case families. To assess the importance of these two mutations in another ‘high-risk’ group, young women (under age 51) with multiple primaries, we screened a large population-based series of young women with bilateral breast cancer and compared the frequency of these mutations among similar women diagnosed with unilateral breast cancer. The 1149 women… CONTINUE READING

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