ATM stabilizes DNA double-strand-break complexes during V(D)J recombination

Abstract

The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA-damaging agents. ATM deficiency leads to ataxia-telangiectasia, a disease marked by lymphopenia, genomic instability and an increased predisposition to lymphoid malignancies with… (More)
DOI: 10.1038/nature04866

4 Figures and Tables

Topics

  • Presentations referencing similar topics