ATM specifically mediates repair of double-strand breaks with blocked DNA ends

@inproceedings{lvarezQuiln2014ATMSM,
  title={ATM specifically mediates repair of double-strand breaks with blocked DNA ends},
  author={Alejandro {\'A}lvarez-Quil{\'o}n and Almudena Serrano-Ben{\'i}tez and Jenna Ariel Lieberman and Cristina Carnerero Quintero and Daniel S{\'a}nchez-Guti{\'e}rrez and Luis M. Escudero and Felipe Cort{\'e}s-Ledesma},
  booktitle={Nature communications},
  year={2014}
}
Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator of signalling following DNA double-strand breaks (DSBs) has been dissected in extraordinary detail, but the impact of this process on DSB repair still remains controversial. Here we develop novel genetic and molecular tools to modify the structure of DSB ends and demonstrate… CONTINUE READING
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