ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance

@inproceedings{McKerlie2012ATMRP,
  title={ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance},
  author={Megan A. McKerlie and Sichun Lin and Xu-Dong Zhu},
  booktitle={Nucleic acids research},
  year={2012}
}
Ataxia telangiectasia mutated (ATM), a PI-3 kinase essential for maintaining genomic stability, has been shown to regulate TRF1, a negative mediator of telomerase-dependent telomere extension. However, little is known about ATM-mediated TRF1 phosphorylation site(s) in vivo. Here, we report that ATM phosphorylates S367 of TRF1 and that this phosphorylation renders TRF1 free of chromatin. We show that phosphorylated (pS367)TRF1 forms distinct non-telomeric subnuclear foci and that these foci… CONTINUE READING

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