ATM regulates ATR chromatin loading in response to DNA double-strand breaks

@article{Cuadrado2006ATMRA,
  title={ATM regulates ATR chromatin loading in response to DNA double-strand breaks},
  author={Myriam Cuadrado and B{\'a}rbara Mart{\'i}nez-Pastor and Matilde Murga and Luis Ignacio Toledo and Paula Gutierrez-Martinez and Eva L{\'o}pez and Oscar Fern{\'a}ndez-Capetillo},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={297 - 303}
}
DNA double-strand breaks (DSBs) are among the most deleterious lesions that can challenge genomic integrity. Concomitant to the repair of the breaks, a rapid signaling cascade must be coordinated at the lesion site that leads to the activation of cell cycle checkpoints and/or apoptosis. In this context, ataxia telangiectasia mutated (ATM) and ATM and Rad-3-related (ATR) protein kinases are the earliest signaling molecules that are known to initiate the transduction cascade at damage sites. The… CONTINUE READING

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