ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.

@article{Gatei2011ATMPP,
  title={ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.},
  author={Magtouf H. Gatei and Burkhard Jakob and Philip S Chen and Amanda Wraith Kijas and Olivier J. Becherel and Nuri Gueven and Geoff Birrell and Ji-Hoon Lee and Tanya T Paull and Yaniv Lerenthal and Shazrul Fazry and Gisela Taucher-Scholz and Reinhard Kalb and Detlev Schindler and Regina Waltes and Thilo D{\"o}rk and Martin Francis Lavin},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 36},
  pages={31542-56}
}
The Mre11/Rad50/NBN complex plays a central role in coordinating the cellular response to DNA double-strand breaks. The importance of Rad50 in that response is evident from the recent description of a patient with Rad50 deficiency characterized by chromosomal instability and defective ATM-dependent signaling. We report here that ATM (defective in ataxia-telangiectasia) phosphorylates Rad50 at a single site (Ser-635) that plays an important adaptor role in signaling for cell cycle control and… CONTINUE READING
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