ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.

@article{SegalRaz2011ATMmediatedPO,
  title={ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.},
  author={Hava Segal-Raz and Gilad Mass and Keren Baranes-Bachar and Yaniv Lerenthal and Shih-Ya Wang and Young Min Chung and Shelly Ziv-Lehrman and Cecilia E. Str{\"o}m and Thomas Helleday and Mickey C-T Hu and David J. Chen and Yosef Shiloh},
  journal={EMBO reports},
  year={2011},
  volume={12 7},
  pages={
          713-9
        }
}
The cellular response to double-strand breaks (DSBs) in DNA is a complex signalling network, mobilized by the nuclear protein kinase ataxia-telangiectasia mutated (ATM), which phosphorylates many factors in the various branches of this network. A main question is how ATM regulates DSB repair. Here, we identify the DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) as an ATM target. PNKP phosphorylates 5'-OH and dephosphorylates 3'-phosphate DNA ends that are formed at DSB termini caused… CONTINUE READING

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