ATM-like kinases and regulation of telomerase: lessons from yeast and mammals.

@article{Sabourin2008ATMlikeKA,
  title={ATM-like kinases and regulation of telomerase: lessons from yeast and mammals.},
  author={Michelle Sabourin and Virginia A. Zakian},
  journal={Trends in cell biology},
  year={2008},
  volume={18 7},
  pages={337-46}
}
Telomeres, the essential structures at the ends of eukaryotic chromosomes, are composed of G-rich DNA and asociated proteins. These structures are crucial for the integrity of the genome, because they protect chromosome ends from degradation and distinguish natural ends from chromosomal breaks. The complete replication of telomeres requires a telomere-dedicated reverse transcriptase called telomerase. Paradoxically, proteins that promote the very activities against which telomeres protect… CONTINUE READING

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