ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.

  title={ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.},
  author={Laura Biddlestone-Thorpe and Muhammad Sajjad and Elizabeth Rosenberg and Jason M. Beckta and Nicholas C K Valerie and Mary E. Tokarz and Bret R. Adams and Alison F Wagner and A Abd el Raouf Khalil and Donna Gilfor and Sarah E. Golding and Sumitra Deb and David G Temesi and Alan Lau and Mark J. O'Connor and Kevin S Choe and Luis F. Parada and Sang Kyun Lim and Nitai D. Mukhopadhyay and Kristoffer Valerie},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={19 12},
PURPOSE Glioblastoma multiforme (GBM) is the most lethal form of brain cancer with a median survival of only 12 to 15 months. Current standard treatment consists of surgery followed by chemoradiation. The poor survival of patients with GBM is due to aggressive tumor invasiveness, an inability to remove all tumor tissue, and an innate tumor chemo- and radioresistance. Ataxia-telangiectasia mutated (ATM) is an excellent target for radiosensitizing GBM because of its critical role in regulating… CONTINUE READING


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