ATM is required for the cellular response to thymidine induced replication fork stress.

@article{Bolderson2004ATMIR,
  title={ATM is required for the cellular response to thymidine induced replication fork stress.},
  author={Emma Bolderson and Jennifer Scorah and Thomas Helleday and Carl G W Smythe and Mark Meuth},
  journal={Human molecular genetics},
  year={2004},
  volume={13 23},
  pages={2937-45}
}
Genetically distinct checkpoints, activated as a consequence of either DNA replication arrest or ionizing radiation-induced DNA damage, integrate DNA repair responses into the cell cycle programme. The ataxia-telangiectasia mutated (ATM) protein kinase blocks cell cycle progression in response to DNA double strand breaks, whereas the related ATR is important in maintaining the integrity of the DNA replication apparatus. Here, we show that thymidine, which slows the progression of replication… CONTINUE READING

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