ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

  title={ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins},
  author={M. J. Waterman and E. Stavridi and Jennifer L. F. Waterman and T. Halazonetis},
  journal={Nature Genetics},
  • M. J. Waterman, E. Stavridi, +1 author T. Halazonetis
  • Published 1998
  • Biology, Medicine
  • Nature Genetics
  • The p53 tumour-suppressor protein is a sequence-specific DNA-binding transcription factor that induces cell cycle arrest or apoptosis in response to genotoxic stress. Activation of p53 by DNA-damaging agents is critical for eliminating cells with damaged genomic DNA and underlies the apoptotic response of human cancers treated with ionizing radiation (IR) and radiomimetic drugs. The molecular mechanisms by which DNA damage activates p53 have not been elucidated. Both the levels of p53 protein… CONTINUE READING
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