ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.

@article{Taira2010ATMAN,
  title={ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.},
  author={Naoe Taira and Hiroyuki Yamamoto and Tomoko Yamaguchi and Yoshio Miki and Kiyotsugu Yoshida},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 7},
  pages={4909-19}
}
The tumor suppressor p53 is a transcription factor that regulates cell cycle, DNA repair, senescence, and apoptosis in response to DNA damage. Phosphorylation of p53 at Ser-46 is indispensable for the commitment to apoptotic cell death. A previous study has shown that upon exposure to genotoxic stress, DYRK2 translocates into the nucleus and phosphorylates p53 at Ser-46, thereby inducing apoptosis. However, less is known about mechanisms responsible for intracellular control of DYRK2. Here we… CONTINUE READING

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