ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

@article{Lavin2007ATMAT,
  title={ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks},
  author={Martin Francis Lavin},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={7749-7758}
}
The recognition and repair of DNA double-strand breaks (DSBs) is a complex process that draws upon a multitude of proteins. This is not surprising since this is a lethal lesion if left unrepaired and also contributes to genome instability and the consequential risk of cancer and other pathologies. Some of the key proteins that recognize these breaks in DNA are mutated in distinct genetic disorders that predispose to agent sensitivity, genome instability, cancer predisposition and/or… CONTINUE READING

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Distinct domains in Nbs 1 regulate irradiationinduced checkpoints and apopto

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