ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

  title={ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks},
  author={A. Jazayeri and J. Falck and C. Lukas and J. Bartek and G. Smith and J. Lukas and S. Jackson},
  journal={Nature Cell Biology},
  • A. Jazayeri, J. Falck, +4 authors S. Jackson
  • Published 2006
  • Medicine, Biology
  • Nature Cell Biology
  • It is generally thought that the DNA-damage checkpoint kinases, ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR), work independently of one another. Here, we show that ATM and the nuclease activity of meiotic recombination 11 (Mre11) are required for the processing of DNA double-strand breaks (DSBs) to generate the replication protein A (RPA)-coated ssDNA that is needed for ATR recruitment and the subsequent phosphorylation and activation of Chk1. Moreover, we show that… CONTINUE READING

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