ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

@article{Jazayeri2006ATMAC,
  title={ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks},
  author={Ali Jazayeri and Jacob Falck and Claudia Lukas and Jiri Bartek and Graeme C M Smith and Jiri Lukas and Stephen P. Jackson},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={37-45}
}
It is generally thought that the DNA-damage checkpoint kinases, ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR), work independently of one another. Here, we show that ATM and the nuclease activity of meiotic recombination 11 (Mre11) are required for the processing of DNA double-strand breaks (DSBs) to generate the replication protein A (RPA)-coated ssDNA that is needed for ATR recruitment and the subsequent phosphorylation and activation of Chk1. Moreover, we show that… Expand
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