ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

Abstract

H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein kinase (DNA-PK) plays any role in this response is unclear. Here, we show that H2AX phosphorylation after exposure to… (More)

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Cite this paper

@article{Stiff2004ATMAD, title={ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.}, author={Tom Stiff and Mark O'Driscoll and Nicole Rief and Kuniyoshi Iwabuchi and Markus L{\"{o}brich and Penny A Jeggo}, journal={Cancer research}, year={2004}, volume={64 7}, pages={2390-6} }