ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

@article{Matsuoka2007ATMAA,
  title={ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage},
  author={Shuhei Matsuoka and Bryan A. Ballif and Agata Smogorzewska and E. Robert McDonald and Kristen E. Hurov and Ji Luo and Corey E. Bakalarski and Zhenming Zhao and Nicole L. Solimini and Yaniv Lerenthal and Yosef Shiloh and Steven P. Gygi and Stephen J. Elledge},
  journal={Science},
  year={2007},
  volume={316},
  pages={1160 - 1166}
}
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transduction portion of this pathway are known, but little is known about the physiological scope of the DNA damage response (DDR). We performed a large-scale proteomic analysis of proteins phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR and identified more than 900 regulated… 
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