ATM: genome stability, neuronal development, and cancer cross paths.

@article{Shiloh2001ATMGS,
  title={ATM: genome stability, neuronal development, and cancer cross paths.},
  author={Yosef Shiloh and Michael B. Kastan},
  journal={Advances in cancer research},
  year={2001},
  volume={83},
  pages={
          209-54
        }
}
  • Yosef Shiloh, Michael B. Kastan
  • Published in Advances in cancer research 2001
  • Biology, Medicine
  • One of the cornerstones of the web of signaling pathways governing cellular life and differentiation is the DNA damage response. It spans a complex network of pathways, ranging from DNA repair to modulation of numerous processes in the cell. DNA double-strand breaks (DSBs), which are formed as a result of genotoxic stress or normal recombinational processes, are extremely lethal lesions that rapidly mobilize this intricate defense system. The master controller that pilots cellular responses to… CONTINUE READING

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