ATM: A mediator of multiple responses to genotoxic stress

@article{Rotman1999ATMAM,
  title={ATM: A mediator of multiple responses to genotoxic stress},
  author={G. Rotman and Y. Shiloh},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={6135-6144}
}
The ATM protein kinase is the product of the gene responsible for the pleiotropic recessive disorder ataxia-telangiectasia. ATM-deficient cells show enhanced sensitivity and greatly reduced responses to genotoxic agents that generate DNA double strand breaks (DSBs), such as ionizing radiation and radiomimetic chemicals, but exhibit normal responses to DNA adducts and base modifications induced by other agents. Therefore, DSBs are most likely the predominant signal for the activation of ATM… CONTINUE READING

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