Cells have evoked mechanisms, globally named the DNA damage response (DDR), to detect, signals and repair DNA lesions, which are tightly coordinated with apoptotic or cell cycle arrest responses . Defects in these mechanisms lead to genomic instability, a hallmark of cancer cells. While key components of DDR have now been identified, further research is… (More)
Figures and Tables
Sorry, we couldn't extract any figures or tables for this paper.