ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei

@inproceedings{Brennand2015ATG24RA,
  title={ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei},
  author={Ana Brennand and Eva Vico Rico and Daniel J. Rigden and Patrick Van der Smissen and Pierre J. Courtoy and Paul A. M. Michels and Frank Voncken},
  booktitle={PloS one},
  year={2015}
}
We have previously identified homologs for nearly half of the approximately 30 known yeast Atg's in the genome database of the human sleeping sickness parasite Trypanosoma brucei. So far, only a few of these homologs have their role in autophagy experimentally confirmed. Among the candidates was the ortholog of Atg24 that is involved in pexophagy in yeast. In T. brucei, the peroxisome-like organelles named glycosomes harbor core metabolic processes, especially glycolysis. In the autotrophic… CONTINUE READING

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