ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.

@article{Bommiasamy2009ATF6alphaIX,
  title={ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum.},
  author={Hemamalini Bommiasamy and Sung Hoon Back and Paolo Fagone and Kyungho Lee and Sasha Meshinchi and Elizabeth I. Vink and Rungtawan Sriburi and Matthew Frank and Suzanne Jackowski and Randal J Kaufman and Joseph W. Brewer},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 10},
  pages={1626-36}
}
A link exists between endoplasmic reticulum (ER) biogenesis and the unfolded protein response (UPR), a complex set of signaling mechanisms triggered by increased demands on the protein folding capacity of the ER. The UPR transcriptional activator X-box binding protein 1 (XBP1) regulates the expression of proteins that function throughout the secretory… CONTINUE READING