ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.

@article{Xiao2013ATF4PD,
  title={ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.},
  author={Guozhi Xiao and Ting Zhang and Shibing Yu and Sojin Lee and Virtu Calabuig-Navarro and Jun Yamauchi and Steven Manfred. Ringquist and Henry H. Dong},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 35},
  pages={
          25350-61
        }
}
Hypertriglyceridemia is the most common lipid disorder in obesity and type 2 diabetes. It results from increased production and/or decreased clearance of triglyceride-rich lipoproteins. To better understand the pathophysiology of hypertriglyceridemia, we studied hepatic regulation of triglyceride metabolism by the activating transcription factor 4 (ATF4), a member of the basic leucine zipper-containing protein subfamily. We determined the effect of ATF4 on hepatic lipid metabolism in Atf4… CONTINUE READING
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